Arsenal boss Emery: Martinelli’s long-term position?by Paul Vegas22 days agoSend to a friendShare the loveGabriel Martinelli is set for more action with Arsenal tonight.Martinelli finds himself in line to feature for Arsenal tonight, when they host Standard Liege in the Europa League.Gunners head coach Unai Emery said: “He is with us because he deserves to be with us. Pre-season was his chance to show and to work with us and we are very, very happy with him. He is a very fast player and that is a quality that is very important. “He gives us good pressing without the ball, good pace in the final third, chances to score and he’s getting better. He is young but if his performances are getting better every day, it is good for him to carry on being with us.”On Martinelli’s long-term position, he added: “We used him in training and against Nottingham Forest as a striker.“It is not the best position for him but he played well and he played there sometimes in Brazil but he can play right or left.” About the authorPaul VegasShare the loveHave your say
Tevin Coleman Hoosiers Trading CardTevin Coleman played three years of football at Indiana, and was one of the top running backs in the Big Ten his last two seasons. He was selected in the third round of the 2015 NFL Draft by the Atlanta Falcons after leaving school with one year of eligibility remaining.Three years was plenty of time for Coleman to establish himself as a star on the gridiron, but apparently not long enough for him to learn to spell IU’s nickname. Trading card company Panini America includes athlete artwork in its packs, and Coleman’s sketch featured a misspelling of the word Hoosiers.Tevin Coleman’s 1 of 1 art card for Panini pic.twitter.com/5bJA1ZrCXj— Darren Rovell (@darrenrovell) June 15, 2015Ouch. That’s a pretty bad mistake by Coleman, and kind of odd that Panini didn’t want him to correct it. The IU faithful probably won’t be happy to see this, though we’re sure they’ll still accept Coleman due to the yeoman’s effort he put forth on the field for a sub-par team.
CALGARY – The former U.S. secretary of energy in the Obama administration says there are no easy answers when it comes to winning public support for critical energy infrastructure projects.American nuclear physicist Ernest Moniz, who was energy secretary from 2013 to 2017, gave a speech in Calgary focusing on the need for innovation to reduce greenhouse gas emissions while still ensuring a supply of energy needed to maintain the North American standard of living.He says there’s no “cookie-cutter solution” to overcome public opposition to projects such as the Energy East pipeline cancelled Thursday by Calgary-based TransCanada Corp. (TSX:TRP).Moniz says the key to winning social licence to build is listening to the community and educating it about the liabilities and benefits the project might offer.He says the recent interest by China in improving its greenhouse gas emissions will have an indirect benefit for Canada in that it will drive a resurgence in world demand for liquefied natural gas.He expects that will translate into at least four more new U.S. LNG export facilities in the next five years, some possibly sourcing Canadian gas, and could provide a market for a Canadian LNG industry.Although about 20 LNG projects have been proposed for British Columbia, only one small project has been approved and two large projects have been cancelled or put on hold because of deteriorating global LNG prices.“I do expect the LNG market to grow substantially. There is a little bit of an oversupply for a few years but longer term, I think it will be a big market,” Muniz said.“For Canada, well, obviously it’s a question of getting product on the water, so there are routes through the United States but Canada has to figure out how to get it either west or east or south.”He says the boom in shale oil and gas production in the United States makes it important for Canada to diversify its energy customer base by finding more routes to ocean export points.
APTN National NewsRegional chiefs arrived at the Assembly of First Nation offices in downtown Ottawa Monday ready to talk about what comes next for the organization now that its national chief has stepped down.There are several options open to the chiefs.APTN’s Annette Francis reports.
Reviewed by James Ives, M.Psych. (Editor)Feb 22 2019In what could serve as a model for tackling one of the nation’s top public health crises, a University of Massachusetts Amherst epidemiology researcher is teaming up with two Western Massachusetts sheriff’s offices to design, implement and study an opioid treatment program for jail detainees in Franklin and Hampshire counties.Funded with a $1.5 million grant from the federal Subtance Abuse and Mental Health Services Administration, the three-year project aims to deliver medications to some 500 detainees who agree to treatment, and connect them to follow-up care through a comprehensive community reentry program after their release.Elizabeth Evans, assistant professor in the School of Public Health and Health Sciences and one of the grant recipients, will collect data from all the stakeholders to measure the project’s outcomes. “The idea is to distill the lessons learned into a playbook or guide that can be used in jails in Massachusetts and across the nation,” Evans says.The opioid crisis has grown so severe that Americans are now more likely to die from an unintentional opioid overdose than in a vehicle crash or any other accident, according to the National Safety Council.Opioid addiction “is probably the issue of the 21st century in terms of public health,” Evans says, and the project reflects a shift in the approach to addressing the crisis. “Evidence supports the use of medications to treat opioid use disorder. This model signifies a willingness of the sheriffs to deliver care to reduce recidivism and to save people’s lives,” she says.Evans will help Franklin County Sheriff Christopher Donelan, Assistant Superintendent Ed Hayes and their staff expand and formalize the groundbreaking opioid treatment they began offering inmates in 2015 at the county jail in Greenfield. She also will work with Hampshire County Sheriff Patrick Cahillane, Assistant Superintendent Melinda Cady and their staff to implement the same program in the Northampton jail.The location of the rural counties along Interstate 91 leaves residents particularly exposed to the effects of opioid trafficking. For many of the jail detainees, it will be their first opportunity to receive evidence-based care for their disorder, Evans says. “This is a health condition,” she says. “And this is a very vulnerable population.”Related StoriesInternational study aims to more accurately describe mental health disordersCombat veterans more likely to exhibit signs of depression, anxiety in later lifeIU-connected startup working to enable precision medicine for mental health issues, chronic painEach of the jails has a medical director who assesses the need for treatment, prescribes the medication and monitors the detainees who receive it. An estimated 40 percent of inmates at both jails report having an opioid problem, Evans says, and most are willing to receive treatment, which can begin in as few as four days after arrest.The treatment medications include Suboxone, which contains buprenorphine and naloxone to help ease cravings and the severe, flu-like symptoms associated with withdrawal; and Vivitrol, an opiate-blocker given as an injection that lasts about a month. Jail authorities also are seeking DEA approval to offer methadone, a synthetic opioid commonly used to treat opioid use disorder.”People who experience withdrawal develop a fear of ever experiencing that again,” Evans says, which helps explain both the cycle of addiction and the high risk of overdose for detainees following their release from jail.According to a 2018 Massachusetts Department of Public Health report, the opioid overdose death rate is 120 times higher for recently released inmates than for other adults. And the first month after release is a critical time.”We recognize that the period after release from jail is a high-risk period for overdose and death from opioids,” Evans says. “The inmates’ tolerance changes and their bodies cannot withstand the same amount of substances as they could pre-incarceration. They often return to use at the same level, which becomes a lethal dose for them.”That’s why connecting people to medication providers and social services after their release from jail is a crucial part of the program, Evans says.Franklin and Hampshire counties are among seven in the Commonwealth in a pilot program mandated by the Massachusetts Legislature to start offering medication to inmates with opioid use disorder by September. Evans says the data gathered from the three-year project in Franklin and Hampshire counties may inform the Commonwealth’s burgeoning plan for jail-based opioid addiction treatment.”Jails used to be all about public safety,” Evans says. “Now they are taking on a public health role. This has potential benefits to both the incarcerated people and to us as a society.” Source:https://www.umass.edu/newsoffice/article/grant-funds-opioid-addiction-treatment-two
Source:Pancreatic Cancer Research Fund Reviewed by Kate Anderton, B.Sc. (Editor)May 28 2019Seven innovative research projects tackling pancreatic cancer have been awarded grants totaling £1.2M by the UK medical research charity, Pancreatic Cancer Research Fund (PCRF).This is the fourth year that the charity has been able to allocate over £1M for research projects and brings its project portfolio spend to over £9M, with an additional £2M committed to the world’s first national pancreas tissue bank, created in 2016 to further accelerate research progress.The new projects span early diagnosis, potential new treatments and fundamental research to find out why immunotherapy does not yet work with pancreatic cancer. They include the progression of promising virotherapy research, a unique technology to tag unwanted proteins and trigger their destruction and testing whether machine learning techniques can help identify those at risk from developing the disease.Maggie Blanks, PCRF’s founder and Chief Executive, said: The seven awards are:Dr Richard Clarkson, Cardiff UniversityNormal cells are programmed to die if they become damaged or diseased in a process called apoptosis, but pancreatic cancer cells contain a molecule called c-FLIP which stalls this process. Dr Clarkson has shown in laboratory tests that blocking c-FLIP from working ‘releases the brakes’ on the anti-tumour process. He now wants to see if this works in mice with pancreatic tumours and will test new ways to block c-FLIP.Professor Laura Itzhaki, University of CambridgeCells stay healthy by tagging faulty proteins with a molecule called ubiquitin that acts like an address label, sending the proteins to be destroyed by the cell’s waste-disposal machinery. Prof Itzhaki has developed a technology that mimics this process, forcing ubiquitin to attach to selected proteins and trigger their destruction. This project will test if the technology can eliminate proteins produced by a faulty gene called KRAS, which is found in many pancreatic cancers.Dr Gunnel Halldén, Queen Mary University of LondonDr Halldén is progressing her PCRF-funded research which aims to use a flu-like virus, delivered into the bloodstream, to seek out and infect pancreatic cancer cells wherever they are in the body. This project will identify new drugs that improve the ability of the virus to replicate inside the cancer cells and spread within the tumour, which should stimulate the immune system to provide long-term protection from the disease coming back.Related StoriesNew protein target for deadly ovarian cancerBacteria in the birth canal linked to lower risk of ovarian cancerUsing machine learning algorithm to accurately diagnose breast cancerDr Naomi Walsh, Dublin City University, Ireland Dr Walsh aims to design chemotherapy drugs that will target and kill types of cancer stem cells within pancreatic tumours that are responsible for drug resistance and relapse. These drugs are designed using new techniques which enable them to be transported directly into the cancer cells. This means that patients could be given smaller doses and experience fewer side effects. It may also allow more patients to benefit from these new treatments.Dr Laura Woods, London School of Hygiene & Tropical Medicine Dr Woods’s project addresses the challenge of diagnosing pancreatic cancer earlier. She will apply ‘machine learning’ techniques to an historic, anonymised database of thousands of GP records to examine whether people who later developed pancreatic cancer shared similar early warning signs detectable before diagnosis. This could provide means of identifying a population of patients whom it would be cost-effective to screen, and increase the number of cancers diagnosed at a treatable stage.Professor Maeve Lowery, Trinity College DublinSome pancreatic cancer patients have faults in genes involved in repairing DNA, such as the BRCA2 gene, which makes the cancer more likely to respond to certain treatments. Professor Lowery will study tumour samples to find changes in different regions of these genes and assess how this affects the response to drugs which target defective DNA repair. She hopes the results will inform a clinical trial where patients are matched with drugs most likely to benefit them.Professor Hemant Kocher, Queen Mary University of London Professor Kocher’s project will investigate why immunotherapy – a treatment which harnesses the patient’s immune system to kill cancer cells – works with some cancers but not with pancreatic cancer. The team will investigate how immune cells interact with each other and are either triggered or dampened in pancreatic cancer. The aim of this project is to determine the most effective way of combining immunotherapy and chemotherapy in future pancreatic cancer clinical trials. Research is the only way we’ll find better ways of tackling pancreatic cancer and we need to keep pushing the boundaries of different research approaches. These projects involve new ideas, new technologies and new techniques that excited our Scientific Advisory Panel and we’re keen to see what they deliver.”
In this April 23, 2019, photo, Chris Williamson poses for a photo sitting on his car in Phoenix. When Williamson was in the market for a new family car, a timely ad and conversations with a co-worker convinced him to try something out of the ordinary. He bought the BMW 3 Series convertible and covers the payments by renting it to strangers on a peer-to-peer car sharing app called Turo. It allows his family of seven to have a nicer car, essentially for free. (AP Photo/Ross D. Franklin) Explore further When Chris Williamson was in the market for a new family car, a timely ad and conversations with a co-worker convinced him to try something out of the ordinary. He bought a BMW 3 Series convertible and covers the payments by renting it to strangers on a peer-to-peer car sharing app called Turo. In this April 29, 2019, photo, Steve Webb, VP of Communications, left, and Andre Haddad, CEO, right, pose in the entryway of Turo in San Francisco. Car-sharing apps that let people rent out their vehicles to strangers are growing in popularity in the U.S. But the people who rent cars through apps like Turo and GetAround don’t pay the taxes and surcharges that local governments and airports tack onto traditional rental cars. (AP Photo/Eric Risberg) Car-sharing apps’ popularity drives debate about taxes “I think everybody was agreed this is a new industry that needs some more regulation,” Peterson said.Both sides portray their position as a matter of fairness.Those supporting stricter regulations say people who rent out their cars for profit should not only pay the taxes but meet the safety and transparency requirements that go with renting a car.”The goal is leveling the playing field,” said Arizona Rep. David Livingston, a Republican who is sponsoring legislation to treat car-sharing firms like rental car companies. “You want all these companies operating with the same type of rules and regulations so they can compete and the best one wins, whoever that is.”Turo’s lobbyists point to the billions of dollars car-rental firms save on taxes. Most states charge no sales tax for vehicles sold exclusively for rental, and allow those companies to pass along vehicle licensing fees to customers.Turo asks why its users should pay rental taxes if they’re not exempt from other vehicle taxes that benefit rental car companies.”Our host community is individuals that are just trying to offset the cost of a car,” said Steve Webb, the company’s vice president of communications. “And Enterprise is this $24 billion Goliath that is using their political connections to stifle innovation.”Turo says more than 95% of Turo’s 197,000 “hosts” share three or fewer cars on the platform. But some of the company’s 350,000 listed vehicles are owned by people who rent out small fleets.Wagner, the Enterprise executive, calls it a “politically motivated fiction” for Turo to focus on taxes paid by people who occasionally list their car.For Williamson, the Phoenix teacher who rents his BMW through Turo, the prospect of his customers having to take on those taxes and surcharges is concerning. The people who rent his BMW are looking to splurge. He also sometimes rents his family’s Honda Pilot SUV.”Any time you start to creep the price up for anything, you’re going to get people who say, ‘Oh, I guess we won’t take the convertible this weekend. We’ll just take whatever Hertz has on special,'” he said. In this April 23, 2019, photo, Chris Williamson poses for a photo sitting next to his car in Phoenix. When Williamson was in the market for a new family car, a timely ad and conversations with a co-worker convinced him to try something out of the ordinary. He bought the BMW 3 Series convertible and covers the payments by renting it to strangers on a peer-to-peer car sharing app called Turo. It allows his family of seven to have a nicer car, essentially for free. (AP Photo/Ross D. Franklin) It allows his family of seven to have a nicer car, essentially for free.”It’s great to have that little bit of extra income and not have to worry about the car payments,” said Williamson, a teacher from the Phoenix area.But his customers and others using car-sharing apps around the United States get their rentals tax-free. That’s made them a target for rental car companies, airport authorities and local governments. They say users of the upstart apps should pay the same taxes and fees that come with traditional rental cars.At stake is hundreds of millions of dollars in revenue that cities and airports count on to pay for stadiums and convention centers or to fund police, fire and other general operations.”These companies are very sophisticated, technology-savvy companies that have hundreds of millions of dollars invested in each of them,” said Ray Wagner, senior vice president for government relations at Enterprise Holdings, parent of the nation’s largest car-rental firm. “They should be expected to comply with the same rules as a small, mom and pop rental car company located in rural Arizona.”Turo says Enterprise is trying to stifle competition.Car-sharing companies including Turo and GetAround function like Airbnb for vehicles, allowing people to rent out their cars when they’re not using them. Founded about a decade ago, they’ve taken off recently with the help of millions of dollars from venture capital firms and other investors.That’s put them in conflict with the $42 billion-per-year rental car industry and the tourism and government agencies that tax it and regulate safety and consumer protections.The battle is heating up in some three dozen state legislatures as well as the courts and offices of local tax authorities. Barraged with lobbying from both sides, lawmakers are grappling with how to regulate an emerging industry without destroying it—a repeat of recent fights between the taxi industry and Uber and Lyft, and between hotels and Airbnb. Citation: States race to regulate car-sharing apps as industry revs up (2019, May 2) retrieved 17 July 2019 from https://phys.org/news/2019-05-car-sharing-legislative_1.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2019 The Associated Press. All rights reserved. “The tragedy would be if we snuffed out something like this in its infancy that has a lot of great potential,” said Arizona Rep. Travis Grantham, a Republican who has introduced legislation backed by Turo that would exempt car-sharing from all rental car taxes except the standard sales taxes. Tourism taxes have long been popular with politicians who can use surcharges on hotel rooms and rental cars—paid largely by visitors who vote elsewhere—to raise money for local priorities.Forty-four states levy excise taxes on rental cars—on top of the standard sales tax, if one applies—and most allow local governments to levy their own as well, according to a March study by the Tax Foundation, a conservative think tank. Airports often add surcharges to pay for sprawling rental-car facilities.Taxes, fees and surcharges can add as much as 30 percent to the cost of renting a car while generating millions of dollars.In metropolitan Phoenix, the baseball league that draws fans to 10 stadiums for spring training every March could see a sharp decrease in revenue as the new platform for car rental grows, said its president, Jeff Meyer. Rental car taxes help cover debt payments for some of the Cactus League’s facilities and for the Arizona Cardinals football stadium.California, Oregon and Washington passed legislation on car-sharing years before the industry took off, and Maryland did so last year. Bills governing the practice have been introduced in more than 30 other states, with the fight especially contentious in Alaska, Arizona, Colorado, Florida, Illinois, New Mexico and Ohio.Turo also is fighting in court with Los Angeles and San Francisco airport authorities, which contend the company should pay fees. Meanwhile, Chicago tax authorities wrote that car-sharing is subject to rental car taxes in response to questions from an Enterprise lawyer, according to a letter provided by the company.In Arizona, Enterprise is backing legislation that would tax car-sharing like rental cars and require them to enter agreements with airports to use their facilities, while Turo supports a proposal that would exempt car-sharing companies from most taxes.In Ohio, a detailed package of new regulations on car-sharing companies was tucked into the House version of the state transportation budget. It came as the Columbus Regional Airport Authority broke ground on a new $140 million car rental facility that relies on a steady stream of car rental user fees.The peer-to-peer companies won a temporary reprieve last month, when the provision was dropped from the bill. But Ohio Sen. Bob Peterson, the No. 2 Republican, said he anticipates a stand-alone regulatory bill will be introduced soon.