Bul hosts Paidah as Kirinya search for maiden victory away to Tooro United

first_imgThe Bul team that started the 1-0 loss to Tooro in their last game (file photo)StarTimes Uganda Premier LeagueTuesday, 16-10-2018-Bul FC vs Paidah Black AngelsNjeru Technical Center, Jinja @04:30pm-Tooro United vs Kirinya JSSKavumba Recreation Grounds, Wakiso @04:30Bul FC will be hoping to iron out their latest home woes when they host newly-promoted Paidah Balck Angels at the Njeru Technical Center on Tuesday afternoon.The Jinja-based side have lost all of their last two home games in the league including a 1-0 defeat to Tooro United at the start of the month.Aside from the recent form, Bul are usually a strong side at home and will be expected to take care of Paidah.“We have no serious injury concerns and this gives us confidence as we face our opponent, said Bul coach Peter Onen.“I am very optimistic about a positive result.“We lost our last fixture but we have done our homework so well I expect the best from my players.For Paidah, they received a harsh welcome to life in the top tier as they went down 2-0 at URA in the first game. However, the Arua based side recovered instantly, defeating Police FC in their last game and will be hoping the same luck befalls them in Jinja.This will be the first ever top flight meeting between the two sides. Both sides start the day with three points each.At Kavumba, Tooro FC will be out to prevent Kirinya JSS from registering a maiden victory this campaign.Tooro United host Kirinya in their third league game (file photo)The Schoolboys from Jinja are yet to taste victory but neither have they lost of their opening two fixtures, having drawn 2-2 with SC Villa and 0-0 with KCCA FC.Clashes between these two sides have always been entertaining affairs but Kirinya JSS have never beaten Tooro United ( Former Soana) in 4 attempts.Tooro United have beaten Kirinya JSS on 2 occasions, and later only managing to pick two points from the remaining clashes.Head coach Charles Ayiekho maintains that despite the record, he is positive that his impressive team are good enough to get their first victory over Tooro“This is a young team that grows in stature each day that passes on, we have always set our targets high and we work hard towards achieving them, said Kirinya coach Charles Ayieko.“Tuesday’s game is very tricky because Tooro is a tough side who are hard to beat, they have quality having signed more than a half of SC Villa’s last season squad.Isaac Isinde will miss tomorrow’s game after traveling with the national team to Maseru-Lesotho, but the inform Joel Madondo is expected to keep Tooro United at tenterhooks.Simon Serunkuuma, Mahad Yaya Kakooza and Allan Kayiwa are expected to lift Tooro United as they try to maintain their dominance over Kirinya.The other game on Tuesday:Police FC vs Express FC, StarTimes Stadium-Lugogo @04:00pmComments Tags: Bul FCkirinya jsspaidah black angelsStarTimes Uganda Premier LeagueTooro unitedlast_img read more

After a tough Winter, beware of the Springtime, “Yes, of course!”

first_imgMost afternoons in the Fall, I like to sit in my kitchen and look into my backyard. With mature trees and an abundance of hiding spaces, I am normally greeted by a series of friends: squirrels, chipmunks, and rabbits. At one point, my nephew tried to give each of them a name, but it was a futile effort and the innocent gesture became too tasking for him. So, we agreed to call them the backyard crew — it was an inclusive name that covered the cardinals, woodpecker, robins, and hummingbirds who often joined the ground crew.Come the Winter months, once all of the leaves had fallen, the grass stopped growing, and the deck was covered with several inches of snow, my backyard crew was nowhere to be found. Sure, we missed them, but, as I explained to my nephew, this is all a part of understanding the cycle of life.Like clockwork, this Spring, there are new editions to the crew — little babies running around, chasing behind momma (or it could be daddy). My nephew is quick to point out, “I don’t think that one was here before.” Helping to explain to him the changing seasons and how squirrels, chipmunks, and rabbits hibernate gave me a better grasp on a pattern that I have observed for almost a decade now — animals aren’t the only ones who hibernate during the Winter months; sometimes our clients disappear on us too.Within some industries and fields, this can mean that a freelancer’s winter months are not as plentiful as others. Couple that with nicer weather and the ambiance of Spring, and some of us may feel tempted to say, “Yes, of course!” to every project that comes our way. However, you may want to take a long pause before you say ‘yes’ and here’s why.The Winter slowdownThe Winter months can be tough for freelancers for various reasons. SAD, seasonal affect disorder, is a condition that can affect anyone. The shorter days, darker days, colder nights and less natural sunlight in some parts of the country can alter one’s mood, sense of relevancy, creativity, motivation and overall emotional well-being. When you add the multiple holidays that occur between November and mid-March, some of us, and even our clients, may feel overwhelmed and/or depleted.Clients’ projects may get pushed back to a later season and warmer weather. On the surface, this is good news — your Spring calendar may fill up quickly. However, you want to make sure that your decision to take on a project is not determined exclusively by a depletion model.Before you say, “Yes, of course!” make sure that you really mean it. Otherwise, there is a strong possibility that you might take on a project that you would normally pass on.Finding balanceUncertainty and angst can be a double-edged sword for any freelancer. Yes, we need to generate income; yes, we want to remain viable and productive, and yes, we enjoy what we are doing and would prefer not to have unplanned breaks. All of these statements ring true. But, I can also tell you from firsthand experience that we often make mistakes when we are being too myopic.I can also tell you that a tough Winter will, eventually, end. We also know that at the end of Winter, evidence of new birth will appear. I am literally looking at small bulbs forming on the daffodils in my front yard. Much like the cycles and seasons that govern nature, be sure to come out of Winter with a renewed sense of purpose and passion. If a project isn’t going to be a good fit, don’t be afraid to say “no” or “tell me more…” Trust the process that has led to your success thus far and trust that something else will come along.In other words, the adage “something is better than nothing” should not apply if you are coming out of a tough season. Be mindful that your decision-making may be deeply vested in a desire to recoup the revenue that you didn’t make during the Winter months. My advice: Don’t focus on rebounding; instead, hone in on rebuilding and renewal — much like the backyard crew.last_img read more

Scientists grow bullish on pigtohuman transplants

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Genetically engineered pigs produced in Munich, Germany, were recently used in a record-breaking baboon heart transplant. Teams focusing on kidney and heart transplants now have results they’re eager to share with regulators. In the past couple of years, they have managed to dampen—though not eliminate—the violent immune response that transplanted pig organs normally provoke in monkeys. Earlier this year, a team at Emory University in Atlanta, Georiga, announced that a kidney from a genetically engineered pig had sustained a rhesus macaque monkey for more than 400 days before being rejected, breaking the record by more than 250 days. And today, a group of researchers headed by Bruno Reichart at the University of Munich in Germany announced they had nearly doubled the previous survival record for a life-sustaining pig heart transplant in a baboon, to 90 days.The study’s experimental design required that the group stop the experiment at 3 months, though the baboon was still “in very good condition,” University of Munich cardiac surgeon Paolo Brenner said after the presentation. It is the first animal to hit a milestone, set nearly 20 years ago by the International Society of Heart and Lung Transplantation, for determining whether a xenotransplantation approach is safe enough to try in humans, Brenner notes. The society’s guidelines are that 60% of animals in a study should survive at least 3 months. Brenner’s team is now working to repeat the results in more baboons, and they hope to launch a clinical trial in 2 or 3 years.That’s good news for a field that went through a protracted period of hard times. After a flood of optimism and investment in the early 1990’s, the struggle to overcome host immune response and fears that organs could transmit pig viruses to humans scared off pharmaceutical funders. But new immunosuppressant drug regimens and a wealth of new genetically engineered pig varieties have changed the equation, says transplant immunologist David Cooper of the University of Alabama in Birmingham. With gene-editing tools such as CRISPR, scientists can now eliminate immune-provoking sugars from the surface of pig cells, introduce human genes that regulate blood coagulation to prevent dangerous clots, and snip out viral sequences that some fear could infect a human host.“We feel much more encouraged than we did even 2 years ago,” Cooper says. His group is exploring kidney transplants from another genetically engineered pig variety, and expects to apply for permission to start a U.S. clinical trial by the end of next year.For all the optimism, researchers are far from being able to offer patients an organ with a lifetime warranty. They are still discovering new mechanisms of immune rejection and debating which genetic changes to pigs are best. And other organs pose bigger challenges. The lung, for example, has proved highly sensitive to inflammation, and experimental animals have survived only a handful of days.What’s more, any whole organ transplant will for now require a cocktail of immunosuppressant drugs that could leave patients vulnerable to infections. That’s a big obstacle to commercial success, says Martine Rothblatt, CEO of United Therapeutics Corporation in Silver Spring, Maryland. The company has invested in xenotransplantation research focused on lung disease, and owns Revivicor, a major supplier of genetically engineered pigs. To be a commercial hit, xenotransplantation “must touch tens and hundreds of thousands of people,” she says. “I do not believe such a large number of transplants is likely with poorly tolerated organs that need to be beaten down with immunosuppressants.”But that’s likely to be the state of play for the first pioneering patients, if whole pig organs make it to the clinic. Cooper points to the many people with kidney failure forced to spend hours a week in blood-filtering dialysis treatment. For these patients, even a temporarily functional pig kidney might be valuable as they wait for an available human kidney. “If you offered them a year off dialysis, they would probably think that’s pretty good,” Cooper says. “You have to start somewhere.” BALTIMORE, MARYLAND—Add your name to a waitlist for a kidney transplant in the United States today, and you’ll join around 100,000 people, many of whom have already been waiting years. The scarcity of life-saving organs for transplants has raised hopes for substitute organs from pigs, which have a similar anatomy to humans. But decades of scientific setbacks have kept clinical trials of that approach, called xenotransplantation, on the horizon.Now, a few teams are chomping at the bit. Exhilarated by recent results in monkey experiments, some researchers here at a meeting of the International Xenotransplantation Association are eyeing human testing.“What we thought was very far away seems to be coming to the near future,” says Muhammad Mohiuddin, a cardiac transplant surgeon at the University of Maryland School of Medicine here. He moderated a premeeting session where scientists discussed advances with officials of the U.S. Food and Drug Administration, which would review any application for a clinical trial. Jan-Michael Abicht Click to view the privacy policy. Required fields are indicated by an asterisk (*)center_img Scientists grow bullish on pig-to-human transplants Email Sign up for our daily newsletter Get more great content like this delivered right to you! Country By Kelly ServickSep. 22, 2017 , 1:47 PMlast_img read more